Issue link: https://optometricmanagementsupplements.epubxp.com/i/587112
16 S P E C I A L E D I T I O N 2 0 1 5 • O P T O M E T R I C M A N A G E M E N T . C O M Tese abilities derive from the amphiphilic nature of PVP that allows it to bind hydrophilic as well as hydro- phobic components. Te uniform, nanoscale distribution of PVP through- out the lens allows the material to interact with the ocu- lar environment in such a way that water and tear flm components can spread homogenously across and throughout the lens, with minimal heterogeneous pre- cipitation or deposition, so that the lens works with key tear components. 10 Recognizing that demanding days require innova- tive materials and design, ACUVUE OASYS 1-Day with HydraLuxe Technology contact lenses take advantage of the most advanced tear flm and contact lens science. Te continuous lubrication and moisturizing made possible by precisely formulated PVP combined with the daily disposable modality make these lenses ones that will help keep your patients comfortable throughout their de- manding days. OM BART A. JOHNSON is the senior manager of Daily Disposable Sphere R&D; at Johnson & Johnson Vision Care, Inc. BRIAN PALL, O.D., M.S., is senior principal research optometrist, Johnson & Johnson Vision Care, Inc. CHARLES SCALES, Ph.D., is principal scientist for Johnson & Johnson Vision Care, Inc., in Jacksonville, Fla. To comment on this article, visit tinyurl. com/OMcomment. REFERENCES 1. Mantelli F, Argüeso P. Functions of ocular surface mucins in health and disease. Curr Opin Allergy Clin Immunol. 2008;8(5):477-83. 2. de Souza GA, Godoy LM, Mann M. Identifcation of 491 proteins in the tear fuid proteome reveals a large number of proteases and protease inhibitors. Genome Biology. 2006;7(8):R72. 3. Rantamäki AH, Seppänen-Laakso T, Oresic M, et al. Human tear fuid lipidome: from composition to function. PLoS One. 2011;6(5):e19553. doi: 10.1371/ journal.pone.0019553. 4. Abelson M, Dartt D, McLaughlin J. Mucins: Foundation of A Good Tear Film. Review of Ophthalmology. November 7, 2011. www.reviewofophthalmology.com/ content/d/therapeutic_topics/c/30968. Accessed September 2, 2015. 5. Green-Church KB, Butovich I, Willcox M, et al. The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Tear Film Lipids and Lipid–Protein Interactions in Health and Disease. Invest Ophthalmol Vis Sci. 2011;52(4):1979-93. 6. Defnition and Classifcation of Dry Eye Disease: Report of the defnition and classifcation subcommittee of the international Dry Eye WorkShop (2007). Ocul Surf. 2007;5(2):75-92. 7. Nichols JJ, Willcox MDP, Bron AJ, et al. The TFOS International Workshop on Contact Lens Discomfort: Executive Summary. Invest Ophthalmol Vis Sci. 2013;54:TFOS7-TFOS13. 8. Nichols JJ, Sinnott LT. Tear flm, contact lens, and patient-related factors associated with contact lens-related dry eye. Invest Ophthalmol Vis Sci. 2006;47:1319-28. 9 Polyvinylpyrrolidone. National Library of Medicine. Accessed September 4, 2015: http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@ DOCNO+205. 10. Oasys patents: US5998498, US6270218, US6367929, US6822016, US6943203, US7461937, US6020445, US6849671, US7052131, US7396890, US7666921, US7691916, US7825170, US8399538, US8450387 D458023, D465416, D496790, D503087, and RE37558. Tear-Infused Design HydraLuxe Technology • Consists of a uniform tear-like network throughout the lens (not a coating) • Works continuously all day (not blink-released) • Works with key tear components (not just water) Article in Brief • The tear flm is complex, with at least 18 mucins, 491 proteins, and 153 lipids. • Ideally, the contact lens should mimic the tear flm. • HydraLuxe Technology is an enhanced network of tear- like molecules that enables ACUVUE OASYS 1-Day to integrate with and support the tear flm. Please see page 4 for more important prescribing information. FE ATURE INSPIRED BY THE SCIENCE OF TE ARS